In the summer of 1493, Rodrigo Borgia, Alexander VI, has been pope for almost a year. Having played a crucial role in helping him ascend the chair of Saint Peter, Francesca, haunted by the shadows of her own past, is now charged with keeping him there. As court poisoner to the most notorious and dangerous family in Italy, this mistress of death faces a web of peril, intrigue, and deceit that threatens to extinguish the light of the Renaissance. As dangers close in from every direction, Francesca conceives a desperate plan that puts her own life at risk and hurls her into a nightmare confrontation with a madman intent on destroying all she is pledged to protect. From the hidden crypts of fifteenth-century Rome to its teeming streets alive with sensuality, obsession, and treachery, Francesca must battle the demons of her own dark nature to unravel a plot to destroy the Borgias, seize control of Christendom, and plunge the world into eternal darkness.